CX-6258 Hydrochloride
CX-6258
CAS: 1353859-00-3
Molecular Formula: C26H25Cl2N3O3
CX-6258 Hydrochloride - Names and Identifiers
CX-6258 Hydrochloride - Physico-chemical Properties
| Molecular Formula | C26H25Cl2N3O3 |
| Molar Mass | 498.4 |
| Storage Condition | Inert atmosphere,Room Temperature |
| In vitro study | CX-6258 showed anti-proliferative activity against a panel of human cancer cell lines with an IC50 of 0.02-3.7 μm, most sensitive to acute leukemia cell lines. CX-6258 combined with doxorubicin (10:1 molar ratio), and CX-6258 combined with paclitaxel (100:1 molar ratio) produced synergistic cell killing, Composite Index (CI50). Values were 0.4 and 0.56, respectively. CX-6258 dose-dependently inhibited the phosphorylation of two pro-survivin proteins, Bad and 4E-BP1, at specific sites of Pim kinase S112 and S65 and T37/46, respectively. CX-6258 showed antiproliferative activity against a panel of human cancer cell lines with an IC50 of 0.02-3.7 μm, most sensitive to acute leukemia cell lines. CX-6258 combined with doxorubicin (10:1 molar ratio), and CX-6258 combined with paclitaxel (100:1 molar ratio) produced synergistic cell killing, Composite Index (CI50). Values were 0.4 and 0.56, respectively. CX-6258 dose-dependently inhibited the phosphorylation of two pro-survivin proteins, Bad and 4E-BP1, at specific sites of Pim kinase S112 and S65 and T37/46, respectively. |
| In vivo study | CX-6258 showed dose-dependent efficacy, inhibiting tumor growth in MV-4-11 of xenografted mice, and producing 45% tumor growth inhibition (TGI) at a dose of 50 mg/kg, the 100 mg/kg dose produced 75% TGI CX-6258 showing dose-dependent efficacy in inhibiting tumor growth in xenografted mice by MV-4-11, the 50 mg/kg dose produced 45% tumor growth inhibition (TGI) and the 100 mg/kg dose produced 75% TGI |
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CAS: 1353859-00-3
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CAS: 1353859-00-3
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Product Name: CX-6258 Visit Supplier Webpage Request for quotation
CAS: 1353859-00-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 1353859-00-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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